中华护理杂志 ›› 2019, Vol. 54 ›› Issue (6): 843-849.DOI: 10.3761/j.issn.0254-1769.2019.06.008
杨丽平,张志刚(),张彩云,魏花萍,孟文勃,岳伟岗,姚丽,丁楠楠,田金徽
收稿日期:
2019-02-12
出版日期:
2019-06-15
发布日期:
2019-06-15
通讯作者:
作者简介:
杨丽平:女,硕士,主管护师,护士,E-mail: <email>114559573@qq.com</email>
基金资助:
YANG Liping,ZHANG Zhigang(),ZHANG Caiyun,WEI Huaping,MENG Wenbo,YUE Weigang,YAO Li,DING Nannan,TIAN Jinhui
Received:
2019-02-12
Online:
2019-06-15
Published:
2019-06-15
摘要:
目的 应用累积Meta分析方法评价早期活动对ICU机械通气患者病死率的影响。方法 计算机检索中国生物医学文献数据库、中国学术期刊全文数据库、万方数据库、PubMed、Embase、Web of Science Cochrane Library数据库,搜集关于ICU机械通气患者进行早期活动的随机对照试验,检索时限为建库至2018年12月30日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,按发表时间顺序进行累积Meta分析,同时采用试验序贯分析方法,评价研究结果的可靠性及真实性。结果 共纳入16项研究,包括1 928例患者。累积Meta分析结果显示,早期活动对ICU机械通气患者ICU住院期间的病死率累积效应值为[OR=1.43,95%CI(0.83,2.48)],住院期间病死率累积效应值为[OR=0.92,95%CI(0.72,1.18)],试验序贯分析结果显示,累计的信息量没有穿过传统界值,也没有跨过试验序贯分析界值,且未达到期望信息量(5 064例),因此,可能试验组和对照组疗效差异无统计学意义,仍需要更多的试验来证明。结论 现有证据显示,早期活动不增加机械通气患者的病死率。受纳入研究数量和质量的限制,上述结论尚需开展更多研究予以证实。
杨丽平, 张志刚, 张彩云, 魏花萍, 孟文勃, 岳伟岗, 姚丽, 丁楠楠, 田金徽. 早期活动对机械通气患者病死率影响的累积Meta分析[J]. 中华护理杂志, 2019, 54(6): 843-849.
YANG Liping, ZHANG Zhigang, ZHANG Caiyun, WEI Huaping, MENG Wenbo, YUE Weigang, YAO Li, DING Nannan, TIAN Jinhui. Effects of early mobilization on mortality in patients with mechanical ventilation in Intensive Care Unit during hospitalization:a cumulative meta-analysis[J]. Chinese Journal of Nursing, 2019, 54(6): 843-849.
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