8例重度免疫检查点抑制剂相关肺炎合并呼吸衰竭患者的护理

doi:10.3761/j.issn.0254-1769.2025.07.016

摘要/Abstract

摘要：

总结8例非小细胞肺癌患者使用程序性死亡受体1抑制剂导致出现重度免疫检查点抑制剂相关肺炎合并呼吸衰竭的护理体会。护理要点：实施目标导向性氧合管理，降低肺损伤风险；采取集束化护理措施，预防肺部感染或感染再加重；严密观察病情变化，早期识别并处理消化道出血及低钙血症；定期随访和宣教，提高疾病自我监测及管理能力。经过精心治疗和护理，6例康复出院，2例疾病发生进展放弃治疗；随访患者1~6周，5例恢复良好，1例1周后死亡。

Abstract:

To summarize the nursing experience of 8 patients with non-small cell lung cancer with severe immune checkpoint inhibitor-related pneumonia complicated with respiratory failure caused by programmed death receptor 1 inhibitor. Nursing points：implementing target-oriented oxygenation management to reduce the risk of lung injury；bundled care measures should be taken to prevent pulmonary infection and infection aggravation；closely observing the changes of the disease，early identification and treatment of gastrointestinal bleeding and hypocalcemia；regular follow-up and health education to improve the ability of disease self-monitoring and management. After careful treatment and nursing，6 cases recovered and were discharged from hospital，while 2 cases gave up treatment；after 1 to 6 weeks of follow-up，5 cases recovered well and 1 case died after 1 week.

Key words: Severe Immune Checkpoint Inhibitor-Related Pneumonia, Programmed Death Receptor 1 Inhibitors, Respiratory Failure, Critical Care

徐美, 方晓眉. 8例重度免疫检查点抑制剂相关肺炎合并呼吸衰竭患者的护理[J]. 中华护理杂志, 2025, 60(7): 871-875.

XU Mei, FANG Xiaomei. Nursing care of 8 patients with severe immune checkpoint inhibitor-related pneumonia complicated with respiratory failure[J]. Chinese Journal of Nursing, 2025, 60(7): 871-875.

图/表 1

参考文献 14

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