关键词: 甲氨蝶呤, 异位妊娠, 骨髓抑制, 毒性反应, 产科护理

Abstract:

To summarize rescuing and nursing experience of 3 ectopic pregnancy patients，suffering from severe toxicity caused by low-dose methotrexate（MTX） treatment. The key points include：constantly monitoring of patients for at least a week after MTX administration，and identifying MTX toxicity related symptoms as soon as possible；promptly establishing a multidisciplinary medical team to establish individualized rescue plans；quickly initiating the rescue therapy and implementing targeted fluid management to accelerate MTX excretion；intensifying protective isolation caring to prevent and control infection；applying refined safety management to prevent spontaneous bleeding；providing intensive caring of skin and mucosal toxicity symptoms to promote healing process；supplying individualized psychological counseling and support in time；strengthening the protection of the damaged organ. After emergent rescuing and intensive nursing，all 3 patients successfully recovered and were discharged from the hospital.

Key words: Methotrexate, Ectopic Pregnancy, Myelosuppression, Toxicity Reaction, Obstetrical Nursing