关键词: 乳腺肿瘤, 化疗相关认知障碍, 非药物干预, 证据总结, 循证护理学

Abstract:

Objective To retrieve，evaluate and summarize the available evidence on non-pharmacological interventions for chemotherapy-related cognitive impairment among breast cancer patients. Methods We searched UpToDate，BMJ best practice，Guidelines International Network，National Institute for Health and Care Excellence，Scottish Intercollegiate Guidelines Network，Registered Nurses’ Association of Ontario，National Comprehensive Cancer Network，Cochrane Library，Joanna Briggs Institution Library，PubMed，Web of Science，CINAHL，SinoMed，CNKI and Wanfang to collect relevant literature including clinical decision support，evidence summaries，clinical practice guidelines，expert consensuses and systematic reviews published from database construction to May 14 of 2023. 2 researchers independently evaluated the quality of literature，extracted and summarized the best evidence. Results A total of 21 articles were included，including 1 clinical decision support，1 evidence summary，1 guideline and 18 systematic reviews. Finally，16 items of evidence were summarized into the following 6 categories：safety and effectiveness，self-management education，cognitive rehabilitation，physical activities，mindfulness-based interventions and multimodal intervention. Conclusion The best evidence summarized in this study is generally with high quality，which can serve as a guidance for clinical staff to provide evidence-based and effective non-pharmacological interventions to breast cancer patients with chemotherapy-related cognitive impairment. We should also take the characteristics of clinical environment and patients’ individual differences into consideration during the application of evidence.

Key words: Breast Neoplasms, Chemotherapy-Related Cognitive Impairment, Non-Pharmacological Interven-tions, Evidence Summary, Evidence-Based Nursing