Objective To develop a Self-Management Demand Scale for infertile patients with obese polycystic ovary syndrome（PCOS） suitable for domestic socio-cultural background，and to test its validity and reliability. Methods Based on the self-management model，the item pool of the scale was constructed through literature review，semi-structured interviews，and Delphi expert consultation. Using convenience sampling method，560 obese PCOS combined with infertility patients from a tertiary-level hospital in Wuhan City were selected for questionnaire survey from June to November 2023，and they were divided into 2 parts according to the time of survey for exploratory factor analysis and validation factor analysis. Results Finally，554 valid questionnaires were collected. The Self-Management Demand Scale for infertile patients with obese PCOS contains 3 dimensions and 37 entries. Exploratory factor analysis extracted 3 factors with the cumulative variance contribution rate of 78.785%. The results of the validation factor analysis showed a good model fit. The content validity indices at the scale entry level ranged from 0.830 to 1.000，and the content validity indices at the scale level were 0.920. The Cronbach’s α coefficients for the scale as a whole were 0.967，and those for the dimensions ranged from 0.890 to 0.971；the split-half reliabilities of the overall scale as a whole were 0.856 and the split-half reliabilities of the dimensions were 0.802~0.895. Conclusion The scale has ideal validity and reliability，which provided a scientific tool to measure accurately the self-management demands of the infertile patients with obese PCOS.