Objective To explore the process and main behavior characteristics of behavioral characteristics of patients with recurrent hypoglycemia in the degeneracy of blood glucose management. Methods A mixed-method convergent design was used to collect data. From June 2022 to April 2023，382 patients with recurrent hypoglycemia were admitted to the endocrine department of a tertiary hospital in Jiangsu were recruited to score of ego depletion. K-means clustering was conducted to analyze the distribution characteristics of patients’ characteristics in blood glucose management. At the same time，19 patients who were selected from the participants of the quantitative study were recruited to attend semi-structured interviews. Results Quantitative results analysis：the average score of blood glucose management loss was（49.20±6.58），and the average scores of cognitive control，behavioral control and emotional control were（17.90±4.12），（15.49±3.64） and （15.81±3.58），respectively. The results of cluster analysis showed that behavioral characteristics could be divided into 3 groups：a cognitive depletion group，an emotional depletion group and a self-control group. Qualitative data analysis：the process of deterioration of management in patients included 3 major themes，including the antecedents of ego depletion，the process of ego depletion and the aftereffects of ego depletion. Analysis of the mixed results showed that the status of ego depletion is serious；patients ignore the behavioral elements of active participation in blood glucose management，show many irrational decision-making behaviors，and the degradation behavior characteristics of patients’ blood glucose management are different. Conclusion The degeneration behavior of blood glucose management was serious and affected by single or multiple factors，continuously consuming self-control energy and causing ego depletion. To promote the long-term maintenance of blood glucose management，priority should be given to take actions to enhance patients’ perceptions，emotion and behaviors，help them learn about the possible blood glucose changes，improve their understanding and recognition of the value of scientific management.