关键词: 精神分裂症, 用药体验, 用药负担, 用药信念, 混合方法, 护理

Abstract:

Objective To explore the influencing factors of medication experience in patients with schizophrenia based on benefit-risk perception. Methods Patients with stable schizophrenia who were hospitalized in 2 tertiary psychiatric hospitals in Heilongjiang Province from September to December 2023 were selected by convenience sampling method. A convergent mixed method was adopted. In quantitative study，data of 400 patients were collected by general situation questionnaire，Subjective Well-being Under Neuroleptic Treatment Scale，the Living with Medicines Questionnaire，Beliefs about Medication Questionnaire，Positive and Negative Syndrome Scale. Binary logistic regression analysis was used to explore the influencing factors of medication experience in patients with schizophrenia. 15 patients with adverse medication experience in quantitative study were selected for qualitative study，and the interview data were sorted and analyzed according to the topic frame analysis method. Results Quantitative results: medication burden, medication beliefs, and psychiatric symptoms of patients with schizophrenia were influential factors of medication experience（P<0.05）. Qualitative results: the medication experience of schizophrenia patients includes 4 themes，namely perceived necessity of medication，perceived benefit of medication， perceived risk of medication, and the need for multi-party cooperation to improve the medication experience. The results of quantitative and qualitative research are complementary in terms of perceived benefit，consistent in terms of perceived risk，and expansive in terms of perceived value. Conclusion Psychiatric nurses can reduce patients’ perceived risk of medication，enhance the perceived benefit of medication，and then improve patients’ adverse medication experience and promote mental rehabilitation.

Key words: Schizophrenia, Medication Experience, Medication Burden, Medication Belief, Mixed Methods, Nursing Care