中华护理杂志 ›› 2022, Vol. 57 ›› Issue (23): 2825-2833.DOI: 10.3761/j.issn.0254-1769.2022.23.002
温萌(), 豆欣蔓, 苗晓琦, 付仲霞, 柳正丽(), 刘晶, 孙宥涵, 严俊
收稿日期:
2021-12-17
出版日期:
2022-12-10
发布日期:
2022-12-05
通讯作者:
柳正丽,E-mail:519379148@qq.com作者简介:
温萌:女,硕士,主管护师,E-mail:461680483@qq.com
基金资助:
WEN Meng(), DOU Xinman, MIAO Xiaoqi, FU Zhongxia, LIU Zhengli(), LIU Jing, SUN Youhan, YAN Jun
Received:
2021-12-17
Online:
2022-12-10
Published:
2022-12-05
摘要:
目的 通过系统评价的方法分析肿瘤患者完全植入式静脉输液港(totally implantable venous access ports,TIVAP)导管相关性血栓形成的危险因素。方法 计算机检索PubMed、Embase、Web of Science、Cochrane Library、中国生物医学文献数据库、中国知网、万方数据库和维普数据库,检索有关肿瘤患者TIVAP导管相关性血栓形成危险因素的病例对照研究和队列研究,检索时限均为建库至2021年8月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果 共纳入22项研究,包括4项病例对照研究和18项队列研究,共10 526例患者。Meta分析结果显示,肿瘤临床分期Ⅲ~Ⅳ期[OR=3.06,95%CI(2.16,4.35),P<0.001]、胸壁静脉植入[OR=0.69,95%CI(0.53,0.89),P=0.005]、体重指数≥25[OR=1.95,95%CI(1.21,3.13),P=0.006]、肿瘤发生转移[OR=2.72,95%CI(1.38,5.38),P=0.004]、硅胶材质导管[OR=0.73,95%CI(0.56,0.95),P=0.020]、高凝状态[OR=2.69,95%CI(1.94,3.73),P<0.001]及糖尿病史[OR=0.50,95%CI(0.33,0.76),P=0.001]是肿瘤患者TIVAP导管相关性血栓形成的独立危险因素。结论 输液港植入位置及其材质、肿瘤临床分期、肿瘤发生转移、体重指数、伴随高凝状态、糖尿病史为肿瘤患者TIVAP导管相关性血栓形成的影响因素。对具有以上影响因素的高危患者应加强临床护理,以降低导管相关性血栓发生率,改善患者临床预后。
温萌, 豆欣蔓, 苗晓琦, 付仲霞, 柳正丽, 刘晶, 孙宥涵, 严俊. 肿瘤患者完全植入式静脉输液港导管相关性血栓形成危险因素的Meta分析[J]. 中华护理杂志, 2022, 57(23): 2825-2833.
WEN Meng, DOU Xinman, MIAO Xiaoqi, FU Zhongxia, LIU Zhengli, LIU Jing, SUN Youhan, YAN Jun. Risk factors for catheter-related thrombosis in cancer patients with totally implantable venous access ports:a Meta-analysis[J]. Chinese Journal of Nursing, 2022, 57(23): 2825-2833.
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