静脉血栓栓塞症复发预测模型的研究进展

doi:10.3761/j.issn.0254-1769.2020.11.021

摘要/Abstract

摘要：

静脉血栓栓塞症患者停用口服抗凝药后复发率较高,严重影响其生活质量。该文从适用人群、评价指标、预测性能等方面对国外近年来发布的静脉血栓栓塞症复发预测模型进行综述,总结国内外的研究现状,旨在为国内静脉血栓栓塞症复发预测模型的构建及应用提供参考。

关键词: 静脉血栓栓塞症, 复发, 预测模型, 护理

Abstract:

After discontinuation of oral anticoagulants,venous thromboembolism in patients with high recurrence rates seriously affects the quality of life. This paper reviews the recurrence of venous thromboembolism prediction model from the applicable people,predict performance and evaluation indexes published abroad in recent years. This review summarizes the current research status at home and abroad for recurrence of venous thromboembolism in China,aiming to provide references for the construction and use of prediction model.

Key words: Venous Thromboembolism, Recurrence, Prognostic Models, Nursing Care

李靖,李星,赵琼,王彦艳. 静脉血栓栓塞症复发预测模型的研究进展[J]. 中华护理杂志, 2020, 55(11): 1723-1727.

LI Jing,LI Xing,ZHAO Qiong,WANG Yanyan. Research progress on the prognostic models for recurrent venous thromboembolism[J]. Chinese Journal of Nursing, 2020, 55(11): 1723-1727.

参考文献 38

[1]	Martins TD, Annichino-Bizzacchi JM, Romano A, et al. Principal component analysis on recurrent venous thromboembolism[J]. Clin Appl Thromb Hemost, 2019,25:1421673445.
[2]	Prandoni P, Noventa F, Ghirarduzzi A, et al. The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism[J]. Haematologica, 2007,92(2):199-205. DOI URL PMID
[3]	Lauber S, Limacher A, Tritschler T, et al. Predictors and outcomes of recurrent venous thromboembolism in elderly patients[J]. Am J Med, 2018,131(6):703-707. DOI URL PMID
[4]	Cohen AT, Katholing A, Rietbrock S, et al. Epidemiology of first and recurrent venous thromboembolism in patients with active cancer. A population-based cohort study[J]. Thromb Hae most, 2017,117(1):57-65.
[5]	Kearon C, Akl EA, Ornelas J, et al. Antithrombotic therapy for VTE disease:CHEST guideline and expert panel report[J]. Chest, 2016,149(2):315-352. DOI URL PMID
[6]	中国健康促进基金会血栓与血管专项基金专家委员会,中华医学会呼吸病学分会肺栓塞与肺血管病学组,中国医师协会呼吸医师分会肺栓塞与肺血管病工作委员会. 医院内静脉血栓栓塞症防治与管理建议[J]. 中华医学杂志, 2018,98(18):1383-1388.
	China Council for the promotion of health foundation,thrombosis and vascular special fund committee of experts,Pulmonary Embolism and Pulmonary Vascular Disease Group-Respiratory Society-Chinese Medical Association,Working Com-mittee of Pulmonary Embolism and Pulmonary Vascular Disease of Respiratory Physicians Branch of Chinese Medical Doctors Association. Suggestions on prevention and management of venous thromboembolism in hospital[J]. Natl Medi J Chin, 2018,98(18):1383-1388.
[7]	Rodger MA, Kahn SR, Wells PS, et al. Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy[J]. CMAJ, 2008,179(5):417-426. DOI URL PMID
[8]	Rodger MA, Scarvelis D, Kahn SR, et al. Long-term risk of venous thrombosis after stopping anticoagulants for a first un-provoked event:a multi-national cohort[J]. Thromb Res, 2016,143:152-158. DOI URL PMID
[9]	Rodger MA, Le Gal G, Anderson DR, et al. Validating the HER-DOO2 rule to guide treatment duration for women with unprovoked venous thrombosis:multinational prospective cohort management study[J]. BMJ, 2017,356:j1065. DOI URL PMID
[10]	Couturaud F, Pernod G, Presles E, et al. Six months versus two years of oral anticoagulation after a first episode of unprovoked deep-vein thrombosis. The PADIS-DVT randomized clinical trial[J]. Haematologica, 2019,104(7):1493-1501. DOI URL PMID
[11]	Eichinger S, Heinze G, Jandeck LM, et al. Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism:the Vienna prediction model[J]. Circulation, 2010,121(14):1630-1636. DOI URL PMID
[12]	Eichinger S, Heinze G, Kyrle PA. D-dimer levels over time and the risk of recurrent venous thromboembolism:an update of the Vienna prediction model[J]. J Am Heart Assoc, 2014,3(1):e467.
[13]	Tritschler T, Mean M, Limacher A, et al. Predicting recurrence after unprovoked venous thromboembolism:prospective validation of the updated Vienna prediction model[J]. Blood, 2015,126(16):1949-1951. DOI URL PMID
[14]	Tosetto A, Iorio A, Marcucci M, et al. Predicting disease recurrence in patients with previous unprovoked venous thromboembolism:a proposed prediction score(DASH)[J]. J Thromb Haemost, 2012,10(6):1019-1025. DOI URL PMID
[15]	Tosetto A, Testa S, Martinelli I, et al. External validation of the DASH prediction rule:a retrospective cohort study[J]. J Thromb Haemost, 2017,15(10):1963-1970. DOI URL PMID
[16]	MacDonald S, Chengal R, Hanxhiu A, et al. Utility of the DASH score after unprovoked venous thromboembolism;a single centre study[J]. Br J Haematol, 2019,185(3):631-633. DOI URL PMID
[17]	Frere C, Benzidia I, Marjanovic Z, et al. Recent advances in the management of cancer-associated thrombosis:new hopes but new challenges[J]. Cancers(Basel), 2019,11(1):71.
[18]	Louzada ML, Carrier M, Lazo-Langner A, et al. Development of a clinical prediction rule for risk stratification of recurrent venous thromboembolism in patients with cancer-associated venous thromboembolism[J]. Circulation, 2012,126(4):448-454. DOI URL
[19]	Astruc N, Ianotto JC, Metges JP, et al. External validation of the modified Ottawa score for risk stratification of recurrent cancer-associated thrombosis[J]. Eur J Intern Med, 2016,36:e11-e12. DOI URL PMID
[20]	Delluc A, Miranda S, Exter PD, et al. Accuracy of the Ottawa score in risk stratification of recurrent venous thromboembolism in patients with cancer-associated venous thromboembolism:a systematic review and meta-analysis[J]. Haematolo-gica, 2020,105(5):1436-1442.
[21]	Piran S, Schulman S. Management of recurrent venous thromboembolism in patients with cancer:a review[J]. Thromb Res, 2018,164(Suppl 1):S172-S177. DOI URL
[22]	Gran OV, Braekkan SK, Paulsen B, et al. Occult cancer-related first venous thromboembolism is associated with an increased risk of recurrent venous thromboembolism[J]. J Thromb Hae-most, 2017,15(7):1361-1367.
[23]	Timp JF, Braekkan SK, Lijfering WM, et al. Prediction of recurrent venous thrombosis in all patients with a first venous thrombotic event:the Leiden Thrombosis Recurrence Risk Prediction model(L-TRRiP)[J]. PLoS Med, 2019,16(10):e100-2883.
[24]	Timp JF, Lijfering WM, Flinterman LE, et al. Predictive value of factor VIII levels for recurrent venous thrombosis:results from the MEGA follow-up study[J]. J Thromb Haemost, 2015,13(10):1823-1832. DOI URL PMID
[25]	Jacobsen BK, Eggen AE, Mathiesen EB, et al. Cohort profile:the Tromso Study[J]. Int J Epidemiol, 2012,41(4):961-967. DOI URL PMID
[26]	Ahmad A, Sundquist K, Zoller B, et al. Association between TLR9 rs5743836 polymorphism and risk of recurrent venous thromboembolism[J]. J Thromb Thrombolysis, 2017,44(1):130-138. DOI URL PMID
[27]	Long B, Koyfman A, Gottlieb M. Risk of recurrent venous thro-mboembolism and bleeding in cancer patients treated with direct oral anticoagulants versus low-molecular-weight heparin[J]. Acad Emerg Med, 2020,27(2):170-172. DOI URL PMID
[28]	Albertsen IE, Søgaard M, Goldhaber SZ, et al. Development of sex-stratified prediction models for recurrent venous throm-boembolism:a Danish nationwide cohort study[J]. Thromb Hae-most, 2020,120(5):805-814.
[29]	Bradbury C, Fletcher K, Sun Y, et al. A randomised controlled trial of extended anticoagulation treatment versus standard treatment for the prevention of recurrent venous thromboembolism(VTE) and post-thrombotic syndrome in patients being treated for a first episode of unprovoked VTE(the ExACT study)[J]. Br J Haematol, 2020,188(6):962-975. DOI URL PMID
[30]	李海燕, 李蓉, 植艳茹, 等. 中老年患者院内发生静脉血栓栓塞症风险预测模型的研究[J]. 中华护理杂志, 2020,55(1):68-73.
	Li HY, Li R, Zhi YR, et al. Study on risk prediction model of in-hospital venous thromboembolism in middle-aged and elder-ly patients[J]. Chin J Nurs, 2020,55(01):68-73.
[31]	田凌云, 王丽倩, 曾佳琪, 等. 儿童静脉血栓栓塞症风险评估模型的研究进展[J]. 中华护理杂志, 2020,55(3):462-467.
	Tian LY, Wang LQ, Zeng JQ, et al. Research progress in the risk assessment model of venous thromboembolism in children[J]. Chin J Nurs, 2020,55(3):462-467.
[32]	石朝利, 周海霞, 唐永江, 等. 内科静脉血栓栓塞症患者复发的危险因素及简化肺栓塞严重指数的预测价值[J]. 中华医学杂志, 2016,96(14):1112-1115.
	Shi CL, Zhou HX, Tang YJ, et al. Risk factors of venous thromboembolism recurrence and the predictive value of simplified pulmonary embolism severity index in medical inpatients[J]. Natl Medi J Chin, 2016,96(14):1112-1115.
[33]	蔡诗凝, 张玉侠, 陈潇. 基于大数据构建危重症患者病情变化预测模型的研究进展[J]. 中华护理杂志, 2018,53(11):1382-1385.
	Cai SN, Zhang YX, Chen X, et al. Research progress of building a prediction model of critically ill patients’ condition change based on big data[J]. Chin J Nurs, 2018,53(11):1382-1385.
[34]	汪鑫, 刘志宇. 泌尿外科围手术期静脉血栓栓塞症预防相关指南介绍及解读[J]. 中华外科杂志, 2018,56(1):18-23.
	Wang X, Liu ZY. Introduction and interpretation of guidelines on thromboprophylaxis in the perioperative period of urological surgery[J]. Chin J Surg, 2018,56(1):18-23.
[35]	中华医学会骨科学分会. 中国骨科大手术静脉血栓栓塞症预防指南[J]. 中华骨科杂志, 2016(2):65-71. DOI URL
	Chinese Medical Association Orthopaedic Society. Chinese gui-delines for the prevention of venous thromboembolism during major orthopedic operations[J]. Chin J Orthopaedics, 2016(2):65-71. DOI URL
[36]	中国临床肿瘤学会肿瘤与血栓专家委员会. 肿瘤相关静脉血栓栓塞症预防与治疗指南(2019版)[J]. 中国肿瘤临床, 2019,46(13):653-660.
	Cancer and Thrombosis Expert Committee of Chinese Society of Clinical Oncology. Guidelines for the prevention and treatment of tumor-associated venous thromboembolism(2019 edition)[J]. Chin J Clini Oncolo, 2019,46(13):653-660.
[37]	张敏, 王勇, 黄俊, 等. 北京市七所综合医院防治静脉血栓栓塞症认知调查及对策分析[J]. 中华医院管理杂志, 2018,34(6):482-486.
	Zhang M, Wang Y, Huang J, et al. Survey of medical staff cognition of the control and treatment of venous thromboembolism at seven general hospitals in Beijing:analysis and countermeasures[J]. Chin J Hospi Administra, 2018,34(6):482-486.
[38]	王晓杰, 徐园, 陈亚萍, 等. 护士静脉血栓栓塞症知识的多中心调查[J]. 中华护理杂志, 2017,52(12):1500-1504.
	Wang XJ, Xu Y, Chen YP, et al. A multicenter survey of know-ledge about prevention of venous thromboembolism in nurses[J]. Chin J Nurs, 2017,52(12):1500-1504.