艾灸改善肿瘤患者血液高凝状态的效果研究

doi:10.3761/j.issn.0254-1769.2024.23.009

摘要/Abstract

摘要：

目的探讨艾灸联合低分子肝素治疗对改善肿瘤患者血液高凝状态的效果。方法采用便利抽样的方法，选择2022年2月—2023年6月上海市某三级甲等中医院肿瘤科住院的128例血液高凝状态的肿瘤患者作为研究对象，采用随机数字表法，将患者分为试验组和对照组，每组各64例。试验组在常规预防措施联合低分子肝素治疗的基础上使用艾灸，干预周期为2个疗程，每个疗程5 d。对照组采用常规预防措施联合低分子肝素治疗。在入组后的第1、6、11天，比较两组血栓弹力图及凝血相关实验室检查指标的差异。结果最终共124例完成研究，试验组和对照组各脱落2例。重复测量方差分析结果显示，两组凝血反应时间存在时间效应（F_时间=8.797，P_时间=0.004）；简单效应分析显示，试验组干预第11天时，凝血反应时间高于第1天，差异具有统计学意义（t=-2.225，P=0.028）。结论艾灸联合低分子肝素治疗能够延长凝血启动时间，降低凝血因子活性，改善肿瘤患者血液高凝状态，从而预防深静脉血栓形成。

关键词: 艾灸, 低分子肝素, 肿瘤患者, 深静脉血栓, 中医护理学

Abstract:

Objective To explore the effect of moxibustion combined with low molecular weight heparin in patients with hypercoagulable tumor. Methods Convenience sampling was used to select 128 patients with high coagulation status of tumors hospitalized in the oncology department of a tertiary A Traditional Chinese Medicine hospital from February 2022 to June 2023 as the research subjects. The patients were randomly divided into an experimental group and a control group by a random number table method，with 64 cases in each group. The control group was treated with conventional prevention and treatment measures combined with low molecular weight heparin，while the experimental group was treated with moxibustion on the basis of measures in the control group. The intervention period was 2 courses，with each course lasting 5 days. The thromboelastography and coagulation indicators of the 2 groups of patients were compared on the 1st，6th，and 11th day after enrollment. Results A total of 124 cases completed the experiment，with 2 cases lost in the experimental group and 2 cases lost in the control group. The results of repeated measures analysis of variance showed that there was a time effect on the coagulation reaction time between the 2 groups（F=8.797，P=0.004）；simple effects analysis showed that on the 11th day of intervention，the coagulation reaction time in the experimental group was higher than 1st day of intervention，and the difference was statistically significant（t=-2.225，P=0.028）. Conclusion Moxibustion combined with low molecular weight heparin can prolong coagulation initiation time，reduce coagulation factor activity，improve hypercoagulability in tumor patients，and thus prevent deep vein thrombosis in tumor patients.

Key words: Moxibustion, Low Molecular Heparin, Tumor Patients, Deep Vein Thrombosis, Traditional Chinese Medicine Nursing

张菁, 张琛, 姜梦媛, 葛燕, 张馨悦, 徐家华. 艾灸改善肿瘤患者血液高凝状态的效果研究[J]. 中华护理杂志, 2024, 59(23): 2873-2877.

ZHANG Jing, ZHANG Chen, JIANG Mengyuan, GE Yan, ZHANG Xinyue, XU Jiahua. Study on the effect of moxibustion in improving hypercoagulable state of tumor patients[J]. Chinese Journal of Nursing, 2024, 59(23): 2873-2877.

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