Objective To apply the best evidence of target temperature management in patients with traumatic brain injury to clinical practice and to evaluate its effect. Methods Followed the application model of JBI evidence-based nursing center,16 review indicators were developed based on the best evidence,and the evidence-based continuous quality improvement model was taken as the theoretical framework. From June 2021 to April 2022,the evidence-based practice was applied to patients with traumatic brain injury in neurosurgery ICU according to the baseline review,practice change and review of change effect after evidence application,and the implementation rate,target temperature management related knowledge level,evidence-based ability,patient complication rate and organizational culture level were compared. Results After evidence-based practice,the implementation rates of the first and second rounds of reviews for various review indicators have improved compared to the baseline,with significant increases in the implementation rates of review indicator 2,3,7,8,9,10,11 and 13(P<0.05). There was a significant decrease in the incidence of grade 3 chills in the 3 groups of patients before and after the baseline review,the first review,and the second review(χ2=7.680,P=0.021). Before and after the implementation of the baseline review,the first round of review,and the second round of review,the scores of the nurses’ knowledge status questionnaire on target temperature management for patients with traumatic brain injury,and the evidence-based practice influencing factors questionnaire were all improved(F=3.827,P=0.025;F=4.997,P=0.009),while the scores of the nurses’ evidence-based nursing practice obstacle scale were lower than those before the implementation(F=4.174,P=0.018). The level of organizational culture has improved compared to it before implementation(F=7.421,P=0.024). Conclusion Through the continuous improvement of evidence-based practice,target temperature management for patients with traumatic brain injury in neurosurgery ICU can effectively standardize the diagnosis and care behavior of medical staff and reduce the incidence of patients’ complications,but it still needs continuous quality supervision and review in the later stage.