Objective To investigate the effect of specialty nurse-led discharge preparation in the perioperative period of lung transplantation patients. Methods Based on the transition theory,literature analysis and expert meetings,the hospital discharge preparation service plan for lung transplant patients was established. We selected 33 lung transplant patients in a tertiary hospital in Zhejiang Province for this study based on convenience sampling,and they were divided into an experimental group and a control group by random number method. The experimental group received the discharge preparation service program led by specialty nurses,and the control group received routine perioperative management of lung transplantation. Data from admission to 3 months after discharge were collected. Between the 2 groups,they were compared on readiness for hospital discharge,reintubation,readmission,and part 2 of Partners at Care Transitions Measure(PACT-M2). Results A statistically significant difference was found in the scores for readiness for hospital discharge,reintubation rate,and Chinese version PACT-M2(P<0.05). There was no significant difference in the number of readmissions 1 month and 3 months after discharge between the 2 groups(P>0.05). Conclusion Specialized nurse-led discharge preparation services for lung transplant patients can improve their readiness for discharge and enhance the quality of self-care at home.