乳腺癌患者内分泌治疗相关症状及非药物干预的研究进展

doi:10.3761/j.issn.0254-1769.2021.04.027

摘要/Abstract

摘要：

乳腺癌已经成为威胁女性健康的常见恶性肿瘤,其发病率和病死率较高。内分泌治疗能有效减少乳腺癌的复发率和病死率,但也给患者带来严重的症状负担。该文对乳腺癌患者内分泌治疗相关的特异性症状及非药物干预方法进行综述,以期为临床护理实践和相关研究提供参考。

关键词: 乳腺癌, 内分泌治疗, 症状, 非药物干预, 护理, 综述

Abstract:

Breast cancer has become the primary malignant tumor that threatens women’s health,and its incidence and fatality rate rank first among female malignancies. Endocrine therapy can effectively reduce the recurrence rate and mortality of breast cancer,but it also brings severe symptoms to patients. This article reviews the specific symptoms and non-pharmacological interventions related to endocrine therapy of breast cancer,with a view to providing references for clinical practice and nursing research.

Key words: Breast Cancer, Endocrine Therapy, Symptoms, Non-Pharmacological Interventions, Nursing Care, Review

荆凤,邢唯杰. 乳腺癌患者内分泌治疗相关症状及非药物干预的研究进展[J]. 中华护理杂志, 2021, 56(4): 635-640.

JING Feng,XING Weijie. Review of symptoms and non-pharmacological interventions among breast cancer survivors undergoing adjuvant endocrine therapy[J]. Chinese Journal of Nursing, 2021, 56(4): 635-640.

参考文献 48

[1]	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018,68(6):394-424. DOI URL PMID
[2]	中国乳腺癌内分泌治疗专家共识专家组. 中国乳腺癌内分泌治疗专家共识(2015年版)[J]. 中国癌症杂志, 2015,25(9):755-760.
	Consensus expert group of Chinese breast cancer endocrine therapy experts. Consensus among Chinese breast cancer endocrinologists(2015)[J]. Chin Oncol, 2015,25(9):755-760.
[3]	Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Aromatase inhibitors versus tamoxifen in early breast cancer:patient-level meta-analysis of the randomised trials[J]. Lancet, 2015,386(10001):1341-1352. DOI URL PMID
[4]	Chan CWH, Tai D, Kwong S, et al. The effects of pharmacological and non-pharmacological interventions on symptom management and quality of life among breast cancer survivors undergoing adjuvant endocrine therapy:a systematic review[J]. Int J Environ Res Public Health, 2020,17(8):2950. DOI URL
[5]	Ochayon L, Tunin R, Yoselis A, et al. Symptoms of hormonal therapy and social support:is there a connection? Comparison of symptom severity,symptom interference and social support among breast cancer patients receiving and not receiving adjuvant hormonal treatment[J]. Eur J Oncol Nurs, 2015,19(3):260-267. DOI URL PMID
[6]	Condorelli R, Vaz-Luis I. Managing side effects in adjuvant endocrine therapy for breast cancer[J]. Expert Rev Anticancer Ther, 2018,18(11):1101-1112. DOI URL PMID
[7]	Zhu Y, Cohen SM, Rosenzweig MQ, et al. Symptom map of endocrine therapy for breast cancer:a scoping review[J]. Cancer Nurs, 2019,42(5):E19-E30. DOI URL PMID
[8]	Sebaoun P, Frederic M, Weryha G, et al. Tolerance of Tamoxifen as an adjuvant therapy and long-term follow up of 55 premenopausal breast cancer women,cared for at the Institute de cancérologie de Lorraine,treated with Tamoxifen[J]. Bull Du Cancer, 2019,106(12S1):S75-S100. DOI URL
[9]	Walker HE, Rosenberg SM, Stanton AL, et al. Perceptions,attributions,and emotions toward endocrine therapy in young women with breast cancer[J]. J Adolesc Young Adult Oncol, 2016,5(1):16-23. DOI URL PMID
[10]	魏盘妹, 顾然, 陈天文, 等. SERM治疗绝经前乳腺癌的不良反应及与预后的相关性[J]. 新医学, 2020,51(2):133-137.
	Wei PM, Gu R, Chen TW, et al. Study on the correlation between the side effects of endocrine therapy of SERM drugs and the prognosis of premenopausal breast cancer patients[J]. New Med, 2020,51(2):133-137.
[11]	李旭, 王浩, 徐红平, 等. 激素受体阳性乳腺癌患者在不同内分泌治疗用药时间的类更年期症状及生命质量[J]. 中华肿瘤杂志, 2020,42(1):55-60.
	Li X, Wang H, Xu HP, et al. Menopausal symptoms and quality of life of hormone receptor positive breast cancer patients at different endocrine therapy time[J]. Chin J Oncol, 2020,42(1):55-60.
[12]	张兴, 花宝金. 芳香化酶抑制剂相关骨关节症状的研究现状[A]. 中华中医药学会,2017年全国中医肿瘤青年论坛论文集[C].北京, 2017: 153-156.
	Zhang X, Hua BJ. Research status of bone and joint symptoms associated with aromatase inhibitors[A]. Chinese Society of Traditional Chinese Medicine,Proceedings of the 2017 National Traditional Chinese Medicine Cancer Youth Forum[C]. Beijing, 2017: 153-156.
[13]	Crew KD, Greenlee H, Capodice J, et al. Prevalence of joint symptoms in postmenopausal women taking aromatase inhibitors for early-stage breast cancer[J]. J Clin Oncol, 2007,25(25):3877-3883. DOI URL PMID
[14]	Beckwée D, Leysen L, Meuwis K, et al. Prevalence of aromatase inhibitor-induced arthralgia in breast cancer:a systematic review and meta-analysis[J]. Support Care Canc, 2017,25(5):1673-1686. DOI URL
[15]	Kelley C. Estrogen and its effect on vaginal atrophy in post-menopausal women[J]. Urol Nurs, 2007,27(1):40-45. URL PMID
[16]	杜华, 潘发明, 丁萍, 等. 乳腺癌术后患者性功能障碍的研究进展[J]. 护理学杂志, 2019,34(6):106-110.
	Du H, Pan FM, Ding P, et al. A review of sexual dysfunction in breast cancer patients[J]. J Nurs Sci, 2019,34(6):106-110.
[17]	NCCN. NCCN Guidelines Version 1.2018 Cancer-Related Fatigue[EB/OL]. (2018-07-26)[2020-06-05]. https://www.nccn.org/professionals/physician_gls/pdf/fatigue.pdf.
[18]	Mao H, Bao T, Shen X, et al. Prevalence and risk factors for fatigue among breast cancer survivors on aromatase inhibitors[J]. Eur J Cancer, 2018,101:47-54. DOI URL PMID
[19]	Bhave MA, Speth KA, Kidwell KM, et al. Effect of aromatase inhibitor therapy on sleep and activity patterns in early-stage breast cancer[J]. Clin Breast Cancer, 2018,18(2):168-174. DOI URL PMID
[20]	Jiang M, Ma Y, Yun B, et al. Exercise for fatigue in breast cancer patients:an umbrella review of systematic reviews[J]. Int J Nurs Sci, 2020,7(2):248-254. DOI URL PMID
[21]	Segal R, Zwaal C, Green E, et al. Exercise for people with cancer:a systematic review[J]. Curr Oncol, 2017,24(4):e290-e315. DOI URL PMID
[22]	Nyrop KA, Callahan LF, Rini C, et al. Aromatase inhibitor associated arthralgia:the importance of oncology provider-patient communication about side effects and potential management through physical activity[J]. Support Care Cancer, 2016,24(6):2643-2650. DOI URL PMID
[23]	Nyrop KA, Callahan LF, Cleveland RJ, et al. Randomized controlled trial of a home-based walking program to reduce moderate to severe aromatase inhibitor-associated arthralgia in breast cancer survivors[J]. Oncologist, 2017,22(10):1238-1249. DOI URL PMID
[24]	Fields J, Richardson A, Hopkinson J, et al. Nordic walking as an exercise intervention to reduce pain in women with aromatase inhibitor-associated arthralgia:a feasibility study[J]. J Pain Symptom Manage, 2016,52(4):548-559. DOI URL PMID
[25]	Irwin ML, Cartmel B, Gross CP, et al. Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors[J]. J Clin Oncol, 2015,33(10):1104-1111. DOI URL PMID
[26]	Thomas GA, Cartmel B, Harrigan M, et al. The effect of exercise on body composition and bone mineral density in breast cancer survivors taking aromatase inhibitors[J]. Obesity(Silver Spring), 2017,25(2):346-351.
[27]	Paulo TRS, Rossi FE, Viezel J, et al. The impact of an exercise program on quality of life in older breast cancer survivors undergoing aromatase inhibitor therapy:a randomized controlled trial[J]. Health Qual Life Outcomes, 2019,17(1):17. DOI URL PMID
[28]	Galantino ML, Greene L, Archetto B, et al. A qualitative exploration of the impact of yoga on breast cancer survivors with aromatase inhibitor-associated arthralgias[J]. Explore(NY), 2012,8(1):40-47.
[29]	Peppone LJ, Janelsins MC, Kamen C, et al. The effect of YOCAS-yoga for musculoskeletal symptoms among breast cancer survivors on hormonal therapy[J]. Breast Cancer Res Treat, 2015,150(3):597-604. DOI URL PMID
[30]	Cramer H, Rabsilber S, Lauche R, et al. Yoga and meditation for menopausal symptoms in breast cancer survivors-a randomized controlled trial[J]. Cancer, 2015,121(13):2175-2184. DOI URL PMID
[31]	宋碧霄. 八段锦对内分泌治疗期乳腺癌患者的体质影响研究[D]. 广州:广州体育学院, 2019.
	Song BX. Ba Duan Jin's influence on the constitution of breast cancer patients during endocrine therapy[D]. Guangzhou Sports College, 2019.
[32]	吴兰. 健身气功八段锦对乳腺癌内分泌治疗期患者生活质量的影响[D]. 广州:广州体育学院, 2018.
	Wu L. Influence of body-building Qigong Ba Duan Jin on quality of life of breast cancer patients in endocrine therapy stage[D]. Guangzhou Sports College, 2018.
[33]	林婉敏, 彭小文. 针灸治疗乳腺癌患者潮热的长期随访研究[J]. 山西中医, 2018,34(3):35-36,38.
	Lin WM, Peng XW. Long-term follow-up study on acupuncture treatment of hot flashes in breast cancer patients[J]. Shanxi J Tradit Chin Med, 2008,34(03):35-36,38.
[34]	Hershman DL, Unger JM, Greenlee H, et al. Effect of acupuncture vs sham acupuncture or waitlist control on joint pain related to aromatase inhibitors among women with early-stage breast cancer:a randomized clinical trial[J]. JAMA, 2018,320(2):167-176. DOI URL PMID
[35]	Pan YQ, Yang KH, Shi XE, et al. Clinical benefits of acupuncture for the reduction of hormone therapy-related side effects in breast cancer patients:a systematic review[J]. Integr Cancer Ther, 2018,17(3):602-618. DOI URL PMID
[36]	Mikhael M, Orr R, Fiatarone Singh MA. The effect of whole body vibration exposure on muscle or bone morphology and function in older adults:a systematic review of the literature[J]. Maturitas, 2010,66(2):150-157. DOI URL
[37]	Baker MK, Peddle-McIntyre CJ, Galvão DA, et al. Whole body vibration exposure on markers of bone turnover,body composition,and physical functioning in breast cancer patients receiving aromatase inhibitor therapy:a randomized controlled trial[J]. Integr Cancer Ther, 2018,17(3):968-978. DOI URL PMID
[38]	Conejo I, Pajares B, Alba E, et al. Effect of neuromuscular taping on musculoskeletal disorders secondary to the use of aromatase inhibitors in breast cancer survivors:a pragmatic randomised clinical trial[J]. BMC Complement Altern Med, 2018,18(1):180. DOI URL PMID
[39]	Hershman DL, Unger JM, Crew KD, et al. Randomized multicenter placebo-controlled trial of omega-3 fatty acids for the control of aromatase inhibitor-induced musculoskeletal pain:SWOG S0927[J]. J Clin Oncol, 2015,33(17):1910-1917. DOI URL PMID
[40]	Lustberg MB, Orchard TS, Reinbolt R, et al. Randomized placebo-controlled pilot trial of omega 3 fatty acids for prevention of aromatase inhibitor-induced musculoskeletal pain[J]. Breast Cancer Res Treat, 2018,167(3):709-718. DOI URL PMID
[41]	NCCN. NCCN clinical practice guidelines in oncology. Survivorship,Version 2. 2019[EB/OL].（2019-10-28）[2020-06-05]. https://www.nccn.org/professionals/physician_gls/default.aspx#supportive.
[42]	Prieto-Alhambra D, Javaid MK, Servitja S, et al. Vitamin D threshold to prevent aromatase inhibitor-induced arthralgia:a prospective cohort study[J]. Breast Cancer Res Treat, 2011,125(3):869-878. DOI URL PMID
[43]	Khan QJ, Kimler BF, Reddy PS, et al. Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms in women with breast cancer receiving adjuvant letrozole. The VITAL trial[J]. Breast Cancer Res Treat, 2017,166(2):491-500. DOI URL PMID
[44]	Shapiro AC, Adlis SA, Robien K, et al. Randomized,blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms(AIMSS)[J]. Breast Cancer Res Treat, 2016,155(3):501-512. DOI URL PMID
[45]	Campbell A, Heydarian R, Ochoa C, et al. Single arm phase Ⅱ study of oral vitamin B12 for the treatment of musculoskeletal symptoms associated with aromatase inhibitors in women with early stage breast cancer[J]. Breast J, 2018,24(3):260-268. DOI URL PMID
[46]	Advani P, Brewster AM, Baum GP, et al. A pilot randomized trial to prevent sexual dysfunction in postmenopausal breast cancer survivors starting adjuvant aromatase inhibitor therapy[J]. J Cancer Surviv, 2017,11(4):477-485. DOI URL PMID
[47]	Hunter MS, Mann E. A cognitive model of menopausal hot flushes and night sweats[J]. J Psychosom Res, 2010,69(5):491-501. DOI URL
[48]	Mann E, Smith MJ, Hellier J, et al. Cognitive behavioural treat-ment for women who have menopausal symptoms after breast cancer treatment(MENOS 1):a randomised controlled trial[J]. Lancet Oncol, 2012,13(3):309-318. DOI URL