关键词: 婴儿, 出生时低体重, 生长和发育, 危险因素, 喂养, 影响因素分析

Abstract: Objective To identify the Geatures o￡ catch-up growth o￡ weight, length and head circumGerence in very low birth weight (VLBW) preterm infants in 12 months of corrected age and to explore the influencing factors. Methods We conducted a retrospective review o￡ medical records o￡ the VLBW preterm in￡ants who were in compliance with inclusion and exclusion criteria and admitted to neonatal intensive care unit (NICU) from January 2014 to March 2016 in one maternity and infant hospital in Shanghai. Infants’ growth chat from Fenton (2003) and Centers for Disease Control and Prevention (CDC) were used for development outcome comparison. We also analyzed the influencing factors of physical growth outcome at 6 and 12 months corrected age. Results A total of 113 VLBW preterm infants were included in this study!of which 106 cases were followed up to 3 months. The outcomes of physical growth in VLBW preterm infants showed significant difference (P<0.05), comparing with other preterm and term infants. For male VLBW preterm infants at 6 months corrected age!longer length of stay, initiating oral feeding later!achieving full oral feeding later and initiating oral feeding with breast milk later were associated with non-optimal length growth & non-optimal weight growth was associated with prolonged length of stay and initiation of oral feeding later (P<0.05). For female VLBW preterm infants at 12 months corrected age!older maternal age and feeding with preterm formulas had negative association with the growth of head circumference (P<0.05 )& older maternal age in NICU was factors influencing weight growth (P<0.05). For male VLBW preterm infants at 12 months corrected age! initiating oral feeding and achieving full oral feeding later negatively impacted on the growth of head circumference (P<0.05) while exclusively feeding with breast milk in NICU was negatively related to length growth (P<0.05). Conclusion Transition to full oral feeding earlier and providing mixed feeding both in-hospital and post-discharge period played important role in VLBW infants’ physical growth. The results suggested feeding counselling in NICU and during follow-up periods is essential for successful catch-up growth in VLBW preterm infants.

Key words: Infant,Very Low Birth Weight, Growth and Development, Risk Factors, Feeding, Root Cause Analysis