Objective To construct and apply an enteral nutrition protocol for patients with intra-abdominal hypertension oriented by intra-abdominal pressure,and provide systematic and standardized interventions for the implementation of enteral nutrition for patients with intra-abdominal hypertension,to reduce the incidence of feeding intolerance and improve the feeding compliance rate. Methods Through literature review and the Delphi method,the enteral nutrition protocol for patients with intra-abdominal hypertension was constructed,and 218 patients with intra-abdominal hypertension admitted to the emergency ICU of a tertiary hospital in Zhejiang Province from January to October 2022 were selected by convenient sampling method. The experimental group used the enteral nutrition protocol for patients with intra-abdominal hypertension oriented by intra-abdominal pressure for enteral nutrition treatment,and the control group used the conventional enteral nutrition treatment in ICU. The incidence of feeding intolerance symptoms,the feeding compliance rate on the 3rd and 7th day of enteral nutrition,the duration of enteral nutrition,and the number of days in ICU were compared between the 2 groups. Results The incidence of feeding intolerance symptoms in the experimental group(58.70%) was lower than that in the control group(74.31%);the feeding compliance rate on the 3rd day of enteral nutrition(31.19%) was higher than that in the control group (16.51%);the rate of feeding on the 7th day of enteral nutrition(28.44%) was higher than that in the control group(13.76%),and the differences were statistically significant(all P<0.05). There was no significant difference in the duration of enteral nutrition and ICU stay between the 2 groups(all P>0.05). Conclusion The enteral nutrition protocol for patients with intra-abdominal hypertension oriented by intra-abdominal pressure has clinical guiding significance,which can reduce the incidence of feeding intolerance and improve the feeding compliance rate in patients with intra-abdominal hypertension.