Objective To systematically evaluate the safety and effectiveness of enteral nutrition in patients with prone ventilation,and to provide references for clinical decision-making. Methods CNKI,WanFang,VIP,SinoMed,PubMed,Embase,Cochrane Library,Web of Science,Clinic trials were searched for randomized controlled trials,quasi-experimental studies and cohort studies about the safety and efficacy of enteral nutrition in patients with prone ventilation published from inception to January 2021. There were 2 reviewers who screened the literature according to the inclusion and exclusion criteria,extracted data,and assessed the quality of included studies indepen-dently. Meta-analysis was conducted by RevMan 5.4. Results Finally,9 articles are included,with a total of 461 patients. The results of meta-analysis showed that compared with patients with supine position,there was no statistical significance for patients with enteral nutrition during prone position in the incidence of high gastric residual volume[OR=0.89,95%CI（0.57,1.38）,P=0.60],the incidence of vomiting or reflux[RR=1.15,95%CI（0.89,1.48）,P=0.29],ventilator associated pneumonia[RR=1.18,95%CI（0.77,1.81）,P=0.44],enteral nutrition interruption rate[RR=1.42,95%CI（0.90,2.24）,P=0.13],length of stay in ICU[MD=-0.63,95%CI（-5.94,4.68）,P=0.82]. Conclusion Enteral nutrition in prone patients had no significant effect on the incidence of high gastric residual volume,vomiting or regurgitation,ventilator-associated pneumonia,enteral nutrition interruption,or length of ICU stay. However,the quality of the included literature is limited,and more high-quality clinical studies are needed for further validation in the future.
