Objective To explore the status of work engagement and its influencing factors,as well as the impact path of big-five personality and work-related acceptance on work engagement of oncology nurses. Methods Nurses from 6 cancer hospitals in 6 provinces and cities in China were randomly sampled using random number table. They were investigated by the general information questionnaire,the big-five personality questionnaire,the Work-related Acceptance and Action Questionnaire(WAAQ),and the Utrecht Work Engagement Scale(UWES). Results The total work engagement score of 1856 nurses from cancer hospitals was 48.55±18.39,with the average item score of 3.24±1.23. Bivariate analysis revealed that work engagement was positively relevant with neuroticism, extraversion, agreeableness, conscientiousness personality, and work-related acceptance(r=0.347,0.237,0.284,0.288,0.541,P<0.01),but negatively correlated with personality of openness(r=-0.077,P<0.01). The multivariate linear regression analysis showed that age,work post,reasons for choosing nursing specialty,working department,type of employment,personality of neuroticism,agreeableness,and work-related acceptance were the independent influencing factors of work engagement(P<0.05),which accounted 37.7% of the total variation. Bootstrap mediation effect analysis demonstrated the partial mediating effect of work-related acceptance between big-five personality and work engagement,which explained 42.11% of the variance. Conclusion The work engagement of nurses from cancer hospitals is at relatively medium level. Hospital administrators should pay attention to the effect of nurses’ personality,promote their work-related acceptance to enhance work engagement.