Chinese Journal of Nursing ›› 2019, Vol. 54 ›› Issue (5): 746-752.DOI: 10.3761/j.issn.0254-1769.2019.05.026

• Evidence Synthesis Research • Previous Articles     Next Articles

Risk factors of venous thromboembolism among patients with chronic obstructive pulmonary disease:a meta-analysis

ZHU Xiaomin,LUO Jian(),LI Miaomiao,XIE Lin,HU Xia   

  • Received:2018-10-31 Online:2019-05-15 Published:2019-05-05
  • Contact: Jian LUO

慢性阻塞性肺疾病患者并发静脉血栓栓塞症危险因素的Meta分析

朱晓敏,罗健(),李苗苗,谢霖,胡霞   

  1. 430030 武汉市 华中科技大学同济医学院附属协和医院护理部(朱晓敏,罗健,谢霖,胡霞),消化内科(李苗苗)
  • 通讯作者: 罗健
  • 作者简介:朱晓敏:女,本科(硕士在读),护士,E-mail: 1783531745@qq.com

Abstract:

Objective To identify the risk factors of venous thromboembolism in patients with chronic obstructive pulmonary disease using meta-analysis.Methods We performed a systematic search in PubMed,Web of Science,Cochrane Library,Embase,MEDLINE,CMB,CNKI,Wanfang Data and VIP to collect studies about risk factors of venous thromboembolism among patients with chronic obstructive pulmonary disease published from inception to May 2018. Data was analyzed by RevMan 5.3 after literature screening,data extraction,and quality appraisal according to criteria by two reviewers independently.Results Fourteen studies were recruited,including 316,297 cases. Fourteen risk factors were involved,among which advanced age,smoking,immobilization,diabetes mellitus and tumor were the main risk factors of venous thromboembolism among patients with chronic obstructive pulmonary disease.Conclusion Because of insufficient evidence on risk factors of venous thromboembolism among patients with chronic obstructive pulmonary disease and sample size of each study varied greatly,the effects of obesity,deep venous catheterization and PaO2 abnormality are still inconclusive,and more high-quality studies are needed to supplement and improve for future research.

Key words: Chronic Obstructive Pulmonary Disease, Venous Thromboembolism, Risk Factors, Meta-Analysis

摘要:

【目的】通过Meta分析明确住院COPD患者发生静脉血栓栓塞症(venous thromboembolism,VTE)的危险因素。【方法】计算机检索PubMed、Web of Science、Cochrane Library、Embase、MEDLINE、中国生物医学文献数据库、中国知网、维普数据库及万方数据库,收集关于COPD患者并发VTE危险因素的研究,检索时限为从建库至2018年5月。由2名评价人员按照标准独立进行文献筛选、资料提取和质量评价后,采用RevMan 5.3软件进行Meta分析。【结果】共纳入14篇文献,包括316 297例研究对象,共14项危险因素。Meta分析显示,高龄、吸烟史、卧床史、合并糖尿病及肿瘤是COPD患者并发VTE的重要危险因素。【结论】高龄患者、有吸烟史和卧床史、合并糖尿病或肿瘤的COPD患者发生VTE的可能性较大。目前关于COPD患者并发VTE危险因素的研究证据尚不充足,且各研究样本量差异较大。肥胖、深静脉置管、PaO2异常的预测价值,证据尚不充分,后期尚需进行更多高质量研究进行验证。

关键词: 慢性阻塞性肺疾病, 静脉血栓栓塞症, 危险因素, Meta分析