This paper summarized nursing experience of 115 patients with infected pancreatic necrosis underwent large-caliber wide channel drainage without necrotic cavity lavage after debridement and drainage. Nursing key point was：① Sustained low negative pressure was applied during bed rest to ensure drainage effect. ② Positive changes of body position were performed to improve drainage effect. ③ Single flushing was conducted using small-dose saline.④ Tube fixed technique should be mastered for large-caliber wide channel drainage.⑤ The occurrence of irritant dermatitis around the wound should be prevented.