Objective To investigate the effects of multiple-modality exercise combined with music imaging on cancer-induced fatigue and negative emotion in nasopharyngeal carcinoma patients with radiotherapy and chemo-therapy.Methods One hundred patients with nasopharyngeal carcinoma who were hospitalized for radiotherapy and chemotherapy in a tertiary hospital in Jiangxi Province were conveniently enrolled and randomly divided into the experimental group and the control group using random number table,with 50 cases in each group. The experimental group received routine nursing and multiple-modality exercise combined with music imaging. The control group received routine nursing of radiotherapy and chemotherapy. The scores of cancer-related fatigue,irritability,depression and anxiety were compared before and after intervention.Results The total scores of cancer-induced fatigue and the total scores of irritability,depression and anxiety in the experimental group were lower than those in the control group,and the difference was statistically significant（P<0.05）.Conclusion Multiple-modality exercise combined with music imaging can effectively alleviate the fatigue during the radiotherapy and chemotherapy of patients with nasopharyngeal carcinoma,and reduce their negative emotions.