To summarize the nursing experience of a child with hepatolenticular degeneration complicated by renal failure undergoing liver transplantation. The main points of nursing include strict monitoring of kidney function,good anticoagulation management,timely adjustment of treatment plans,personalized rehabilitation and diet guidance,strict implementation of disinfection and isolation measures throughout the process,close monitoring of transplanted liver function,and provision of a hospital-family-social support system. After careful treatment and care,the child was discharged on foot 55 days after the operation. The patient was followed up for 6 months and recovered well.