Objective To evaluate the impact of immersive virtual reality（IVR）-based cognitive training on the cognitive function,activity of daily living（ADL） and negative emotion for people with subjective cognitive decline （SCD）,mild cognitive impairment（MCI） or Alzheimer’s disease（AD）. Methods 11 electronic databases,such as PubMed,Embase,CINAHL etc.,and clinical trials registry platforms were searched for related articles published in English and Chinese from inception until April 27th,2021. We retrieved randomized controlled trials or quasi-experience studies focused on IVR-based cognitive training in adults with SCD,MCI or AD. Literature search,study selection,data extraction and methodological quality evaluation were conducted by 2 researchers independently. Meta-analysis was performed by RevMan 5.4. Results 8 studies involving 406 patients were included. Meta-analysis indicated that IVR-based cognitive training significantly enhanced the overall cognition[SMD=0.37,95%CI（0.15,0.60）,P=0.001],short-term memory[SMD=0.62,95%CI（0.19,1.04）,P=0.005] and ADL [SMD=0.84,95%CI（0.57,1.11）,P<0.001] in people with MCI or AD. However,after IVR-based cognitive training,effects on executive function[SMD=-0.24,95%CI（-0.56,0.08）,P=0.140] and long-term memory[SMD=0.00,95%CI（-0.42,0.41）,P=0.990] were not statistically significant in people with MCI or AD,and effects on negative emotion was unclear. Moreover,there was a paucity of intervention studies on IVR-based cognitive training for SCD. Conclusion This meta-analysis suggests that IVR-based cognitive training can provide positive influences on cognitive function and ADL in people with MCI or AD. Due to limited quantity and different interventions of the included studies,more studies with larger sample sizes are required to verify the above conclusions. Moreover,more studies are needed to explore the effects of IVR-based cognitive training for people with SCD.